Bridget
M. Dolan
Graduate Student, Biology Department
Fragile X syndrome is the most common cause of inherited mental retardation and autism. It is caused by the transcriptional silencing of the gene fragile X mental retardation 1 (FMR1). The protein produced by this gene, called FMRP, regulates the shape and function of dendritic spines. The mechanism by which it does this is unclear. My research involves biochemical studies of proteins that interact with or otherwise regulate FMRP. In particular, I am interested in the interaction of FMRP with an actin remodeling protein called PAK.
Publications
| Title | Journal | Date | Authors |
| Calcium channel and NMDA receptor activities
differentially regulate nuclear C/EBP beta levels to control neuronal
survival. |
Neuron. Aug 14; 39(4):625-39 |
2003 | Marshall J, Dolan BM, Garcia EP, Sathe S, Tang X, Mao Z, Blair LA. |
| Fornix-dependent induction of hippocampal CCAAT
enhancer-binding protein [beta] and [delta] Co-localizes with phosphorylated
cAMP response element-binding protein and accompanies long-term
memory consolidation. |
J Neurosci. Jan 1; 21(1):84-91 |
2001 | Taubenfeld SM, Wiig KA, Monti B, Dolan B, Pollonini G, Alberini CM. |
Scholastic Achievements
| Dates | School | Degree |
| 2001 | Brown University | ScB in Biology |
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