Mansuo Lu Hayashi, PH.D.

Postdoctoral Associate & Fellow

The focus of my research is to understand the contribution of synaptic morphological plasticity to learning and memory. In the past few years, we have generated transgenic mice in which catalytic activity of PAK, a critical regulator of actin remodeling, is inhibited in the postnatal forebrain. Cortical neurons in these mice exhibit abnormal synapse number and size, which correlates with impaired cortical bidirectional plasticity and deficient long-term memory. Thus, our results provide evidence for critical relationships between synaptic morphology and bidirectional modifiability of synaptic strength in the cortex, and consolidation of long-term memory.

Publications

Scholastic Achievements

Contact Information