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Learning and Memory in Genetically Engineered Mice
Our primary research interests are the molecular, cellular, and neuronal circuitry mechanisms underlying acquisition, consolidation, and retrieval of hippocampus-dependent memory in rodents. We are also interested in deciphering mechanisms underlying neural activity-dependent development of sensory systems. To study these problems, we produce conditionally engineered (i.e., spatially targeted and/or temporally regulated) mice and analyze these mice by multifaceted methods, including molecular and cellular biology, in vitro and in vivo physiology, and behavioral studies. We attempt to identify deficits at each of the multiple levels of complexity in specific brain areas or cell types and to determine which deficits underlie specific learning or memory, or developmental impairments observed in the mutants.
Susumu Tonegawa
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Tonegawa
Lab is a Member of
The Picower Institute for Learning and Memory at MIT